+2 - the next user will have to draw 2 cards and forfeit their turn.
'No' Symbol - the next user is skipped.Simlarly, if you had three 8 cards in your hand it would make sense to lay one of those. For example, if you had 4 red cards and 1 blue card and the current showing card atop the waste pile allowed you to lay from either color you would choose to lay a red card. It makes sense to try to keep a variety of play options in your hand until you have few cards remaining.